Taxim-O/Taxim-O 400/Taxim-O Kids

Cefixime trihydrate

Taxim-O/Taxim-O Kids Susceptible infections including gonorrhoea, otitis media, pharyngitis, lower resp tract infections eg, bronchitis, & UTI. Taxim-O 400 Uncomplicated UTI caused by E. coli & Proteus mirabilis; uncomplicated gonorrhea caused by N. gonorrhoeae; otitis media caused by H. influenzae (β-lactamase +ve & -ve strains), Moraxella (Branhamella) catarrhalis (most of which are β-lactamase +ve) & Strep pyogenes; pharyngitis & tonsillitis caused by Strep pyogenes; acute bronchitis & acute exacerbations of chronic bronchitis caused by Strep pneumoniae & H. influenzae (β-lactamase +ve & -ve strains).

Taxim-O/Taxim-O 400 Adult 200-400 mg daily as single dose or in 2 divided doses. Uncomplicated cervical/urethral gonococcal infection 400 mg as single oral dose. Childn 8 mg/kg daily as single dose or in 2 divided doses, weighing >50 kg or >12 yr Adult dose. Renal impairment CrCl 21-60 mL/min or patient on renal hemodialysis 75% of standard dose at standard dosing interval (300 mg daily), CrCl <20 mL/min or patient on continuous ambulatory peritoneal dialysis ½ the standard dosage at standard dosing interval (200 mg daily). Taxim-O Kids Childn 5-10 yr 200 mg daily, 1-4 yr 100 mg daily, 6 mth-1 yr 75 mg daily.

May be taken with or without food.

Hypersensitivity to cefixime, cephalosporins or penicillins. Taxim-O/Taxim-O 400 Anaphylactic/anaphylactoid reactions. Patient who demonstrated some form of allergy, particularly to drugs. May alter normal flora of colon & permit overgrowth of clostridia. Severe antibiotic-associated diarrhea including pseudomembranous colitis in patients who develop diarrhea during treatment; exclude other causes of colitis.

False +ve direct Coombs test. Pregnancy & lactation. Childn <6 mth. Taxim-O/Taxim-O 400 Absence of proven or strongly suspected bacterial infection of prophylactic indication may increase risk of development of drug-resistant bacteria. Possibility of emergence of resistant organisms might result in overgrowth particularly during prolonged treatment. Superinfection. Patients w/ renal impairment & undergoing continuous ambulatory peritoneal dialysis & hemodialysis. Monitor patients on dialysis carefully. History of GI disease, particularly colitis. May be associated w/ fall in prothrombin activity in patients w/ renal or hepatic impairment, or poor nutritional state, & receiving protracted course of antimicrobial therapy, & previously stabilized on anticoagulant therapy. Monitor prothrombin time in patients at risk & exogenous vit K administered as indicated. False +ve reaction for ketones in urine may occur w/ tests using nitroprusside; for glucose in urine using Clinitest, Benedict's soln, or Fehling's soln. Taxim-O 400 Contains aspartame which may cause allergic type of reaction including anaphylactic symptoms & life-threatening episodes in certain susceptible persons. Taxim-O Kids Not to be given to patients who are hypersensitive to cefixime or other cephalosporins. Penicillin-sensitive patients may also be allergic to cephalosporins. Patients w/ history of allergy.

Skin rashes, urticaria, eosinophilia, drug fever, serum sickness-like reactions, & anaphylactic/anaphylactoid reactions (including shock & fatalities)/anaphylaxis. Neutropenia & thrombocytopenia. Taxim-O/Taxim-O 400 GI events including diarrhea, loose or frequent stools, abdominal pain, nausea, dyspepsia & flatulence. Severe diarrhea &/or pseudomembranous colitis. Vomiting; pruritus, angioedema, & facial edema, erythema multiforme, SJS; transient elevations in SGPT, SGOT, alkaline phosphatase, hepatitis, jaundice; transient elevations in BUN or creatinine, acute renal failure; headaches, dizziness, seizures; transient leukopenia, prolongation in prothrombin time (rarely); hyperbilirubinemia; genital pruritus, vaginitis, candidiasis, TEN.

Increased prothrombin time w/ warfarin & anticoagulants. Taxim-O/Taxim-O 400 Elevated carbamazepine levels.

Cephalosporins

J01DD08 - cefixime ; Belongs to the class of third-generation cephalosporins. Used in the systemic treatment of infections.

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